Menaquinone 7 belongs to a class of K2-vitamin homologs originally discovered as the anti-hemorrhagic factors. Menaquinone 7 has been identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins, such as osteocalcin and matrix-Gla protein, which play crucial roles in building and maintaining overall bone health. Menaquinone 7 is found in a variety of fermented foods. In vivo, Menaquinone 7 has been shown inhibiting aortic and myocardial calcification. In a rat model of extraosseous clacifciation, Menaquinone 7 decreased aortic alkaline phosphatase tissue concentrations.

Menaquinone 7 is a form of vitamin K2, which includes nine related compounds. Menaquinone 7 is a long-chain menaquinone that is synthesized by Escherichia coli bacteria in the gut. It can be used as a supplement for bone health. Menaquinone 7 can be used as vitamin supplement in health care products.

Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a vari ety of physiological processes. Menaquinone 7 belongs to the class of K2-Vitamins homologs. Menaquinone 7 has been identified as the most bioactive cofactor for the carboxylation reaction of Gla-prote ins such as osteocalcin and matrix-Gla protein, which plays a crucial role in building and maintaining overall bone health.

Reputable Manufacturer Supply Hot Sale 2124-57-4 with Safe Transportation

• Molecular Formula:C46H64O2
• Molecular Weight:649.013
• Vapor Pressure:1.38E-20mmHg at 25°C 
• Melting Point:54 °C 
• Refractive Index:1.532 
• Boiling Point:720.1 °C at 760mmHg 
• Flash Point:254.9 °C 
• PSA：34.14000 
• Density:0.961 g/cm³ 
• LogP:14.09740 

Vitamin K2(35)(Cas 2124-57-4) Usage

Definition	ChEBI: A menaquinone whose side-chain contains seven isoprene units in an all-trans-configutation.
General Description	Vitamin K2, also known as menaquinone, is a polyisoprenoid-substituted?napthoquinone. Menaquinone-7 (MK-7) is a subtype of vitamin K2. It is found in animals, soy protein, fermented products and is primarily produced by bacteria.Vitamin K2 (MK-7)-(5,6,7,8-d4,2-methyl-d3) is a deuterated vitamin K2 wherein C-5, C-6, C-7, C-8, and 2-methyl protons are replaced by deuterium.

InChI:InChI=1/C46H64O2/c1-34(2)18-12-19-35(3)20-13-21-36(4)22-14-23-37(5)24-15-25-38(6)26-16-27-39(7)28-17-29-40(8)32-33-42-41(9)45(47)43-30-10-11-31-44(43)46(42)48/h10-11,18,20,22,24,26,28,30-32H,12-17,19,21,23,25,27,29,33H2,1-9H3/b35-20+,36-22+,37-24+,38-26+,39-28+,40-32+

2124-57-4 Relevant articles

PROCESS OF VITAMIN K2 DERIVATIVES PREPARATION

-

, (2021/04/17)

The invention relates to an improved pro...

Menaquinol Compositions and Methods of Treatment

-

, (2020/04/09)

The present application discloses method...

PROCESS OF VITAMIN K2 DERIVATIVES PREPARATION

-

, (2019/10/29)

Provided is an improved process of vitam...

Convergent Synthesis of Menaquinone-7 (MK-7)

Baj, Aneta,Wa?ejko, Piotr,Kutner, Andrzej,Kaczmarek, ?ukasz,Morzycki, Jacek W.,Witkowski, Stanis?aw

, p. 1026 - 1033 (2016/11/11)

A practical synthesis of menaquinone-7 (...

2124-57-4 Process route

1218784-62-3

2-(3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl)-1,4-dimethoxy-3-methylnaphthalene

2124-57-4,27670-94-6

menaquinone-7

Conditions

Conditions	Yield
With ammonium cerium (IV) nitrate; In water; acetonitrile; at 20 ℃; for 4.08333h;	80%
With ammonium cerium (IV) nitrate; In acetonitrile; at 20 ℃; for 4.08333h;	80%
With ammonium cerium (IV) nitrate; In water; acetonitrile; at 0 ℃; for 0.75h;	72%
With ammonium cerium (IV) nitrate; In dichloromethane; water; acetonitrile; at 0 ℃; for 0.75h;	0.753 g

1597486-88-8

C₅₀H₇₄O₂

2124-57-4,27670-94-6

menaquinone-7

Conditions

Conditions	Yield
With ammonium cerium (IV) nitrate; In dichloromethane; water; acetonitrile; at 0 ℃; for 0.25h;	72%

2124-57-4 Upstream products

• 
  4128-17-0

  (2E,6E)-farnesyl acetate

• 
  93787-91-8

  E,E,E-12-hydroxyfarnesyl acetate

• 
  1597486-72-0

  (2E,6E,10E)-3,7,11-trimethyl-12-(phenylsulfonyl)-dodeca-2,6,10-trien-1-yl acetate

• 
  24163-93-7

  farnesyl bromide

2124-57-4 Downstream products

• 
  1453189-02-0

  3-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-4-hydroxy-2-methylnaphthalen-1-yl benzoate

• 
  1453189-03-1

  4-((diethoxyphosphoryl)oxy)-2-((2E,6E, 10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalen-1-yl benzoate

• 
  1453189-04-2

  4-((diethoxyphosphoryl)oxy)-3-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-2-methylnaphthalen-1-yl benzoate

• 
  1453189-05-3

  4-(((tert-butoxycarbonyl)glycyl)oxy)-2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalen-1-yl benzoate